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Clinical Trial Summary

PANTHER-GI Pilot Study will assess the feasibility of a full-scale multicentre cohort management study evaluating the safety of a standardized strategy for resuming direct oral anticoagulants (DOACs) after major DOAC-related gastrointestinal (GI) bleeding among patients at moderate to high risk of re-bleeding and thrombosis. A parallel registry will assess whether eligible patients who are not enrolled in the PANTHER-GI Pilot Study are systematically different than enrolled patients and to explore barriers to enrolment.


Clinical Trial Description

This pilot cohort management study will evaluate a protocolized strategy for resuming DOACs after major GI bleeding based on thrombotic risk among patients at moderate to high risk of rebleeding. The timeframe for resuming DOACs will be determined based on the patient's underlying thrombotic risk. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05290857
Study type Interventional
Source Ottawa Hospital Research Institute
Contact Deborah M Siegal, MD
Phone 613-737-8899
Email dsiegal@toh.ca
Status Recruiting
Phase N/A
Start date March 31, 2022
Completion date December 2025

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