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DOAC Versus VKA After Cardiac Surgery — DOAC/VKA  

Anticoagulant-induced Bleeding Clinical Trial

Official title:
Oral Anticoagulation After Cardiac Surgery in the Era of Direct Oral Anticoagulants: is Large Use of Vitamin K Antagonists Still Justified?

Clinical Trial Summary

Postoperative management of oral anticoagulation is a frequent preoccupation in cardiac surgery, concerning about half of patients. Vitamin K antagonists are often recommended but their management is not easy due to the high dose-response patient variability. Pharmacologically more stable, direct oral anticoagulants have similar efficiency in preventing thromboembolic complications while they decrease the risk of bleeding in certain patient populations. The objective of study is to assess the safety and efficacy of direct oral anticoagulants in the postoperative period of cardiac surgical procedures.

Clinical Trial Description

This study will be composed by 2 groups of 103 participants, patients undergoing cardiac surgery and needing oral anticoagulation in the early postoperative period. The control group will receive vitamin K antagonist and the study group will receive direct oral anticoagulant. The investigators will call back each participants at 3 months to report the ischemic and bleeding complications during this period and evaluated the quality of life of the oral anticoagulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04002011
Study type Interventional
Source Laval University
Contact
Status Withdrawn
Phase Phase 2
Start date March 9, 2022
Completion date March 9, 2023
View Details
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