Frailty Clinical Trial
Official title:
Frailty Status and Increased Risk for Falls: The Role of Anticholinergic Burden
We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults. Community-dwelling older subjects admitted to the Geriatrics Outpatient Clinic prospectively enter into the study. Frailty status is defined according to the Physical Frailty Phenotype. The drugs are categorized according to the ACB scale
Previous studies have found that the use of drugs with anticholinergic properties relate to
increased prevalence of falls in older women and men. Frailty is associated with serious
health outcomes including falls, hip fractures, and death. Frailty can be a relevant target
to investigate its association with the risk of falls among the users of drugs with
anticholinergic properties. A recent evidence suggests that the interaction between being
frail and adverse outcomes in older adults receiving polypharmacy or centrally acting drugs
is complex and not straightforward across all frailty phenotypes.
We classify the participants frail if they met at least three of five criteria, while those
having one or two criteria were pre-frail, and others were non-frail. We determine the
anticholinergic burden by using the Anticholinergic Cognitive Burden (ACB) Scale developed by
Boustani et al.
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