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Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections

Hysterectomy Clinical Trial

Official title:
Infections After Hysterectomy - a Placebo-controlled Study Comparing the Prophylactic Use of Azithromycin and Cefuroxime With Single Cefuroxime

Clinical Trial Summary

During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%. By reducing post-hysterectomy infections, it is possible to reduce individual burden of disease in addition to the direct and indirect financial costs. This study primary aim is to assess if prophylactic preoperative use of azithromycin in addition to generally used cefuroxime decreases post-hysterectomy infections as compared to cefuroxime only prophylaxis during 30 days after hysterectomy. Secondary aim is to assess if there is change in post-hysterectomy superficial infections, urinary tract infections, or post-operative fever between the cohorts and to report possible side-effects of the used antibiotics. In addition, the study finds out a possible role of bacterial vaginosis and microbiome n post-hysterectomy infections.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05337566
Study type Interventional
Source Helsinki University Central Hospital
Contact Päivi K Rahkola-Soisalo, Adj prof,MD
Phone +358504270411
Email paivi.rahkola-soisalo@hus.fi
Status Recruiting
Phase N/A
Start date September 5, 2022
Completion date December 2030
View Details
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