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Antibiotic Toxicity clinical trials

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NCT ID: NCT05308849 Not yet recruiting - Appendicitis Clinical Trials

Peritoneal Diffusion and Efficacy of Antibiotic Therapy in Pediatric Peritonitis

DIFFUPERPED
Start date: March 31, 2022
Phase: N/A
Study type: Interventional

This is a pilote monocentric prospective study about pediatric peritonitis and antibiotics pharmacokinetic and pharmacodynamic. The investigators will include 41 patients between 3 and 17 years-old during 2 years in the University Hospital of Nancy. The aim of this study is to determine if the beta-lactam dosages in children recommended by the guidelines for management of intra-abdominal infections permitted the achievement of adequatly serum and peritoneal concentrations in the medical and surgical management of peritonitis. The investigators will collected serum and peritoneal fluid samples at 3 different times: peritoneal incision, end of surgery, 2 days and 5 days after surgery in order to compare the concentrations and the minimal inhibitor concentration of bacteria. The hypothesis is that of a serum and peritoneal antibiotic under dosage.