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BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches — LIBRA  

Implementation Science Clinical Trial

Official title:
BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

Clinical Trial Summary

This study will compare two strategies that target distinct determinants of blood culture overuse in an exploratory, hybrid, pilot trial in 8 PICUs. It aims to determine if there is any association between specific strategies used to reduce blood culture overuse on unit-wide blood culture rates, patient safety, and concurrently explore aspects of the implementation process (acceptability, feasibility, appropriateness).

Clinical Trial Description

Blood cultures are an important test to diagnose bacterial bloodstream infections, but can be ordered reflexively, excessively, and lead to downstream negative patient consequences such as unnecessary antibiotic exposure. Work to date has demonstrated safe and effective reduction in blood culture rates in the pediatric intensive care unit (PICU) setting, but optimal strategies to reduce culture use are currently unknown. The primary study team will initially work with all enrolled sites in an identical fashion, facilitating a core series of steps for implementing a quality improvement blood culture diagnostic stewardship program which is identical to the steps used in the parent study, called BrighT STAR (Testing STewardship to reduce Antibiotic use and Resistance). In addition, the primary study team will randomize sites into two arms, in which different strategies are introduced that each target distinct determinants of blood culture overuse. The primary study team will examine the impact on blood culture rates, as well as evaluate aspects of the implementation process, in all sites pre- vs-post intervention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06187662
Study type Interventional
Source Children's Hospital of Philadelphia
Contact
Status Enrolling by invitation
Phase N/A
Start date January 1, 2023
Completion date January 2025
View Details
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