Helicobacter Pylori Infection Clinical Trial
Official title:
Helicobacter Pylori Eradication According to Sequencing-based 23S Ribosomal RNA Point Mutation Associated With Clarithromycin Resistance
The investigators investigated the point mutations in the 23S rRNA genes of patients infected with clarithromycin-resistant H. pylori and compared the H. pylori eradication rates based on the identified clinically significant point mutations.
Sequencing-based detection of point mutations identified four mutations that were considered
clinically significant (A2142G, A2142C, A2143G, A2143C), while all the other mutations were
considered clinically insignificant.
Participants who did not have point mutations related to clarithromycin resistance and/or had
clinically insignificant point mutations were treated with PAC (proton pump inhibitor,
amoxicillin, clarithromycin) for 7 days, while participants with clinically significant point
mutations were treated with PAM (proton pump inhibitor, amoxicillin, metronidazole) for 7
days. H. pylori eradication rates were compared between the two groups.
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