Antibiotic Resistant Strain Clinical Trial
Official title:
Genetic Characterization of Plasmids Carrying Carbapenemases and Quinolone Resistance Determinants in Klebsiella Pneumoniae Isolates in Assiut University Hospitals
NCT number | NCT03767283 |
Other study ID # | HAA |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | July 5, 2019 |
Est. completion date | December 7, 2021 |
Klebsiella pneumoniae is an important pathogen that frequently causes nosocomial
community-acquired and infections, including pneumonia, urinary tract infections, bloodstream
infections, pyogenic liver abscesses, and septic shock.
An emerging co-existence of carbapenems and fluoroquinolone resistance in Klebsiella
pneumoniae is causing major difficulty in treating infections caused by such pathogen
Status | Recruiting |
Enrollment | 50 |
Est. completion date | December 7, 2021 |
Est. primary completion date | June 10, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 2 Years to 50 Years |
Eligibility |
Inclusion Criteria: - admitted to intensive care unite Exclusion Criteria: - healthy |
Country | Name | City | State |
---|---|---|---|
Egypt | Assiut University | Assiut |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Egypt,
Al-Marzooq F, Mohd Yusof MY, Tay ST. Molecular Analysis of Antibiotic Resistance Determinants and Plasmids in Malaysian Isolates of Multidrug Resistant Klebsiella pneumoniae. PLoS One. 2015 Jul 23;10(7):e0133654. doi: 10.1371/journal.pone.0133654. eCollection 2015. — View Citation
Chang CY, Lin HJ, Chang LL, Ma L, Siu LK, Tung YC, Lu PL. Characterization of Extended-Spectrum ß-Lactamase-Carrying Plasmids in Clinical Isolates of Klebsiella pneumoniae from Taiwan. Microb Drug Resist. 2017 Jan;23(1):98-106. doi: 10.1089/mdr.2015.0212. Epub 2016 May 5. — View Citation
Worthington RJ, Melander C. Combination approaches to combat multidrug-resistant bacteria. Trends Biotechnol. 2013 Mar;31(3):177-84. doi: 10.1016/j.tibtech.2012.12.006. Epub 2013 Jan 18. Review. — View Citation
Zhao JY, Zhu YQ, Li YN, Mu XD, You LP, Xu C, Qin P, Ma JL. Coexistence of SFO-1 and NDM-1 ß-lactamase genes and fosfomycin resistance gene fosA3 in an Escherichia coli clinical isolate. FEMS Microbiol Lett. 2015 Jan;362(1):1-7. doi: 10.1093/femsle/fnu018. Epub 2014 Dec 4. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | effect of combined antibiotic therapy on resistance | determination of minimum inhibitory concentration to antibiotics before and after combination | 1 year |
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