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The Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae

Antibiotic Resistant Infection Clinical Trial

Official title:
How to Optimize the Combined Antibiotic Therapy for Carbapenem Resistant Klebsiella Pneumoniae

Clinical Trial Summary

The infection of carbapenem resistant klebsiella pneumoniae (CRKP) is increasingly serious.Based on the early experimental basis and relevant research background,this study intends to separate and purify the CRKP from the bronchoalveolar lavage fluid (BALF) of the clinical patients.Designed by checkerboard assay and time-kill assay(TKA)，this study can explore the best combination therapy based on carbapenems.

Clinical Trial Description

1. Collect the BALF from patients diagnosed with CRKP infection in surgical intensive care unit（SICU）of Shanghai 10th people's hospital.

2. Separate and purify the BALF. Divide each CRKP into four treatment groups based on meropenem.

3.1 By checkerboard method and microdilution broth method,get the minimal inhibitory concentration (MICS) of two antibiotics,then calculate the fractional inhibitory concentration (FIC) index according to MIC results.

3.2 Observe the effect of two antibiotics on the growth of CRKP by TKA.

4.By the above two invitro experiments, analyze the data of the experimental results and get the best combination therapy based on carbapenems. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03950544
Study type Interventional
Source Shanghai 10th People's Hospital
Contact Ma Lao, master
Phone 8613532437896
Email 13532437896@163.com
Status Recruiting
Phase Early Phase 1
Start date January 1, 2019
Completion date December 31, 2020
View Details
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