Anti-bacterial Agents Clinical Trial
Official title:
Effects of Antibiotic Consumption Time on Gingival-biopsy and Oral-smear Samples.
Antimicrobial or antibiotic agents, which are essential to prevent and treat bacterial
infectious diseases, have become one of the most widely used drugs in the world. In the
European region, the highest rates of antibiotic consumption are reported in Turkey. There is
a nearly fivefold difference between Turkey and the lowest consuming countries.
Studies in dentistry evaluate participants according to the basis of predefined criteria.
History of antibiotic consumption is one of the most common exclusion criteria for
periodontal trials. However, there is still disagreement on how long the effect of systemic
antibiotic agents on the oral mucosa and periodontal tissue lasts. It is unclear whether the
timing of antibiotic consumption should be an exclusion criterion for genetic damage and
histological studies during the selection of healthy participants.
Periodontal status of participants in study groups is described as with or without
periodontitis in many studies, because of the lack of clear definitions of periodontal health
and gingivitis. It should be recognized that even the lack of visual signs of inflammation,
some mild histopathological changes can be seen in the periodontium. Consequently, for the
real diagnosis of the clinically healthy periodontium, clinical findings should be supported
and confirmed with histological results.
Micronuclei (Mn) are observed as abnormal nuclear structures and indicators of chromosomal
level DNA damage. The oral mucosa epithelium is an immunologic barrier and affected by
chemical factors such as antibiotic consumption. The Mn test to exfoliated epithelial cells
from the oral cavity is utilized as a non-invasive diagnostic technique for monitoring the
status of oral health. To our knowledge, no studies have been conducted on the comparison of
the impacts of the timing of antibiotic consumption on human periodontal tissues and oral
smear samples. The present study is undertaken to determine whether the different timing of
antibiotic (amoxicillin) therapy has effects on the histopathology of gingiva and genetic
damage of exfoliated cells from oral mucosa in healthy participants.
n/a
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