Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Anti Aging Clinical Trial

Official title:

Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05813379
• Other study ID #: Islamic Azad University
• Status: Recruiting
• Phase: Phase 1/Phase 2
• Start date: February 1, 2022
• Est. completion date: August 30, 2023

Study information

• Verified date: April 2023
• Source: Isfahan University of Medical Sciences
• Contact: Leila Dehghani, Dr
• Phone: +983136201250
• Email: l_dehghani2002[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Aging is a natural and complex process. The effect of environmental factors, genetics on the body eventually leads to damage in different ways. Exosomes are present in almost all body fluids, such as synovial fluid and blood. Exosomes and microvesicles are very efficient mediators of cell-to-cell communication by transferring their specific cargo to recipient cells; for example, exosomes are involved in the delivery of genetic materials, causing epigenetic modifications in the target cells .The applications of MSC-derived exosomes have more effect in cutaneous regeneration by collagen stimulation.The basic biology of exosomes indicates that MSC-exosomes may contain MSC-specific components to exert specific effects on recipient cells, which are somewhat equivalent to the regenerative effects of MSCs. This study aims to slow down the aging process of the skin by using exosome.

Description:

Skin aging is a complex biological process that can be classified into extrinsic or intrinsic aging. Intrinsic aging is an intrinsic degradation process that is caused by a decrease in the proliferation capacity leading to cell senescence. Angiogenesis is essential in various physiological processes, including wound healing and skin tissue regeneration. Literature reviews show that exosomes derived from human umbilical cord blood mesenchymal stem cells can cause Collagen stimulation and reduction of oxidative stress, WNT/βcatenin pathway signaling in the initial stages of causes the regeneration of skin damage . This study aims to slow down the aging process of the skin by using exosome.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: August 30, 2023
• Est. primary completion date: July 29, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 35 Years to 65 Years

Eligibility

Inclusion Criteria:

• females
• Ages 35-65
• Patients of all racial and ethnic origins
• Patients of all undergoing facial rejuvenation

Exclusion Criteria:

• Female patients in pregnancy or menstrual period
• Patients undergoing facial rejuvenation using other methods including Botox injections, chemical peels, face lifts and others
• Patients using blood thinners, aspirin and hormone, that cannot be stopped
• Patients suffering with severe organic disease, such as coronary heart disease, hypertension, diabetes, lung dysfunction and so on
• Patients suffering with mental disease, and acute or chronic infectious diseases

Related Conditions & MeSH terms

• Anti Aging

Intervention

Combination Product:
• exosime injection
Treatment- exosome injection

Locations

Country	Name	City	State
Iran, Islamic Republic of	Isfahan University of Medical Sciences	Isfahan

Sponsors (1)

Lead Sponsor	Collaborator
Isfahan University of Medical Sciences

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proportion of re-epithelialization	In order to evaluate the treatment effect, to evaluate wrinkles and collagen before the treatment, take a photo/CT of the face	1 month
Primary	Proportion of re-epithelialization	In order to evaluate the treatment effect, to evaluate wrinkles and collagen before the treatment, take a photo/CT of the face	3 months