Anterior Temporal Epilepsy Neuropsychological Assessment of Faces

Anterior Temporal Epilepsy Clinical Trial

— ATENA-F  

Official title:

Evaluation of Neuropsychological Effects of Drug-resistant Anterior Temporal Epilepsy and Anterior Temporal Lobectomy in Face Perception

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02888925
• Other study ID #: 2013-A00515-40
• Status: Active, not recruiting
• Phase: N/A
• Start date: August 2013
• Est. completion date: March 2020

Study information

• Verified date: July 2019
• Source: Central Hospital, Nancy, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose is to evaluate neuropsychological effects of anterior temporal epilepsy in face perception by comparison of performances of epileptic patients and control individuals, sex-, age- and socio-educational level-matched.

Secondary purposes are to prospectively evaluate neuropsychological impact of anterior temporal lobectomy performed for surgical treatment of anterior temporal epilepsy on face perception (exploratory study).

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 80
• Est. completion date: March 2020
• Est. primary completion date: September 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

ALL:

• Informed consent

• Affiliation to social security

• Preliminary medical examination

PATIENTS WITH EPILEPSY:

• Symptomatic drug-resistant anterior temporal epilepsy (confirmed with video-electroencephalography and magnetic resonance imaging and if necessary intracerebral SEEG exploration)

• Patient needing anterior temporal lobectomy and undergoing pre-surgery conventional intercritical assessment for surgery decision

• Nonverbal IQ = 70 (WAIS-IV)

• At least 6 successful VOSP tests (perception test)

Exclusion Criteria:

ALL:

• persons under legal protection or incapable to consent

• Persons deprived of liberty by juridical or administrative decision

PATIENTS WITH EPILEPSY:

• Sever visual disorders of neurological or ophthalmological origin

CONTROL INDIVIDUALS:

• Psychiatric or neurological disorders

• Important ophthalmological disorders

Related Conditions & MeSH terms

• Anterior Temporal Epilepsy
• Anterior Temporal Lobectomy
• Epilepsy
• Face Perception

Intervention

Other:
• Mooney test

• Benton Face Recognition test

• Face inversion effect test

• Face composite effect test

• Cambridge Face Memory Test

• Matching different view test

• Memorizing and recognition of new faces test

• Memorizing and recognition of new objects test

• Recognition of celebrities and access to semantic information test

Procedure:
• Lobectomy
In patients with anterior temporal epilepsy, at 6 to 12 months after inclusion, depending on surgery decision taken after pre-surgery conventional intercritical assessment

Locations

Country	Name	City	State
France	Service de Neurologie, Hôpital Central, CHU de Nancy	Nancy

Sponsors (1)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Scores obtained with Benton test by patients with anterior temporal epilepsy and matched control individuals		day 0
Secondary	Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)		day 0 and after 12 to 18 months
Secondary	Change of scores obtained with Benton test by epilepsy patients before and after lobectomy and control individuals (only patients having undergone anterior temporal lobectomy and matched control individuals)		day 0 and after 24 to 30 months