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Clinical Trial Summary

The purpose of this study is to evaluate the clinical efficacy, safety and immunological changes of secukinumab(sec) compared to adalimumab(ada) in patients with active ankylosing spondylitis(AS), who previously have an inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs) or bioagents.


Clinical Trial Description

Biologic naïve participants will be randomly assigned in a 2:1 ratio to receive secukinumab or adalimumab for 24 weeks. Participants with a history of an inadequate response to secukinumab or adalimumab, will be treated with the alternative drug (adalimumab or secukinumab) for 24 weeks. The disease activity and index of inmunology will be evaluated at weeks 0, 12, 24 up to 96 weeks. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05527444
Study type Interventional
Source Qilu Hospital of Shandong University
Contact
Status Active, not recruiting
Phase Phase 4
Start date March 15, 2022
Completion date December 31, 2024

See also
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