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Angina Refractory clinical trials

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NCT ID: NCT04125732 Completed - Clinical trials for Coronary Artery Disease

Epicardial Delivery of XC001 Gene Therapy for Refractory Angina Coronary Treatment (The EXACT Trial)

EXACT
Start date: January 24, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

The primary purpose of this trial is to determine the safety of XC001 (AdVEGFXC1) in patients who suffer from angina caused by coronary artery disease and have no other treatment options. Subjects in this study will receive one of four intramyocardial doses of XC001 that expresses human vascular endothelial growth factor (VEGF) which induces therapeutic angiogenesis (revascularization).

NCT ID: NCT03516643 Completed - Angina Pectoris Clinical Trials

Extracorporeal Shockwave Myocardial Revascularization in Refractory Angina

Start date: January 2009
Phase: N/A
Study type: Interventional

This is a prospective cohort study to examine the efficacy of ESMR application in patients with refractory angina despite optimal medical therapy, not suitable for further PCI or CABG. Characteristics such as angina class scores (CCS class score), nitroglycerin consumption and hospitalization were compared at baseline and 1, 6 and 12 months after ESMR therapy. The effect on cardiac perfusion was assessed at 6 months.