Angina Pectoris Clinical Trial
Official title:
Microvascular Resistance in Women With Chest Pain and no or Minimal Coronary Artery Disease
Female patients presenting with persistent chest pain despite no obstructive coronary artery
disease have impaired prognosis. Stress tests are often positive or inconclusive. As much as
20% of women with chest pain and minimal angiographic CAD have evidence of myocardial
ischemia, suggesting impaired coronary microcirculation. The index of microvascular
resistance (IMR) is a method for indirectly investigating microvascular function in the
cardiac catheterization laboratory.
66 female patients, age 30-70 years, with chest pain and "normal" or near normal coronary
angiograms will be included. After coronary physiologic evaluation, patients will be
randomized in a double blind study to rosuvastatin 20 mg/day or matching placebo tablets for
altogether 6 months.
The investigators hypothesize that:
1. A substantial number of women with chest pain and normal or minimal pathology on
angiograms have microvascular dysfunction defined by a raised IMR.
2. Statins, based on its pleiotropic action will improve endothelial function and thereby
IMR.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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