Angina Pectoris, Variant Clinical Trial
Official title:
Efficacy Study of Atorvastatin to Treat Variant Angina
The objective of this study is to evaluate effect of statin treatment for vasospastic angina.
Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery
accompanying chest pain or discomfort. The precise mechanisms have not been established, but
a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived
relaxing and contracting factors,or an injury of endothelium have been suggested.
Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was
demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment
of statin is documented in several studies.
So, we expect that statin treatment for vasospastic angina provide additional therapeutic
effects via improvement of endothelial dysfunction.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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