Aneuploidy Clinical Trial
Official title:
Aneuploidy Rates of in Vitro Matured Oocytes
In general, nearly 85% of retrieved oocytes are mature and reproductively useful after the
retrieval, whereas the remaining percentage are still at metaphase I or germinal vesicle
stage (MI: 4% and GV: 11 %, respectively).
The objective of our study is to assess if immature oocytes co-cultured with autologous
cumulus cells is a safer strategy than just leaving the oocytes in standard culture.
Under controlled ovarian stimulation, patients with normal functional ovarian reserves
produce a good number of oocytes at retrieval. However, in addition to quantity, oocyte
maturity is an important variable for the success of reproductive technologies. In general,
nearly 85% of retrieved oocytes are mature and reproductively useful, whereas the remaining
percentage are still at metaphase I or germinal vesicle stage (MI: 4% and GV: 11 %,
respectively). Due to the limited expectations held for in vitro maturation in said
stimulated cycles, the rescue of immature oocytes is not widely used in current clinical
practice and these oocytes are usually discarded due to the possibility of abnormal embryonic
development or an increased rate of abortion.
The objective of our study is to assess if immature oocytes co-cultured with autologous
cumulus cells is a safer strategy than just leaving the oocytes in standard culture.
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