Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03553446 |
Other study ID # |
YUMC-2018-04-023 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
July 29, 2018 |
Est. completion date |
April 30, 2021 |
Study information
Verified date |
June 2022 |
Source |
Yeungnam University College of Medicine |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Sevoflurane is as attractive inhalation agent fore deep sedation in children undergoing short
invasive procedure because of lack of irritation to the respiratory tract, a pleasant odor
and rapid clinical effect and recovery due to low blood gas partition coefficient.
The aim of this study is to determine the optimum inspired concentration of sevoflurane
required for immobility during botulinum toxin injection in spontaneously breathing children
with cerebral palsy.
Description:
All anesthetics were administered by a single experienced anesthesiologist. Anesthetic
induction was performed progressively with inhaled 1-8% sevoflurane, if the patient was
cooperative, otherwise directly to the 8%, and subsequent maintenance 2% in oxygen at 5 L
/min. A face mask was connected to a Mapleson C circuit for it. Patients breathed
spontaneously, unaided, via a pediatric face mask. A failure was defined as the patient
continued to move after following the study protocol for sevoflurane inhalation. Insufficient
sedation was treated with increments of 0.5% concentration to achieve the desired effect, ie,
maintenance of immobility during botulinum toxin injection. The sevoflurane concentration in
the next patient would be adjusted depending on the success or failure for immobility at
given sevoflurane concentration ( if successful, 0.5% lower concentration, if failed, 0.5%
higher concentration).
The child was recovered from sevoflurane sedation at the end of botulinum toxin injection and
transferred to post-anesthetic care unit.