Blood Levels of Sevoflurane and Desflurane

Anesthetics, Inhalation Clinical Trial

Official title:

Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03015350
• Other study ID #: One lung ventilation
• Status: Completed
• Phase: N/A
• First received: December 27, 2016
• Last updated: March 2, 2018
• Start date: December 2016
• Est. completion date: December 2017

Study information

• Verified date: November 2017
• Source: Cukurova University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Description:

Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue.

All collection will assess with gas chromatography.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: December 2017
• Est. primary completion date: December 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 25 Years to 65 Years

Eligibility

Inclusion Criteria: ASA I-II patients

• Who undergo thoracotomy or abdominal surgery

Exclusion Criteria:

• ASA IV and up patients

• Patients who taken inotropic agent

Related Conditions & MeSH terms

• Anesthetics, Inhalation

Intervention

Drug:
• Sevoflurane
Measurement of blood desflurane level during one lung ventilation
• Desflurane
Measurement of blood desflurane level during one lung ventilation

Locations

Country	Name	City	State
Turkey	Ebru Biricik	Adana	In The USA Or Canada, Please Select...

Sponsors (1)

Lead Sponsor	Collaborator
Cukurova University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of blood levels of Sevoflurane and Desflurane	Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed.	from 40th minute to the end of the operation
Secondary	determine of ventilation-perfusion mismatch with p(A-a)O2	During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses	from 40th minute to the end of the one lung ventilation