Anesthesia, Obstetrical Clinical Trial
Official title:
Effectiveness of Subarachnoid Hyperbaric Bupivacaine on Mean Arterial Blood Pressure in Pregnant Patients With Obesity Operated by Cesarean Section
Verified date | December 2019 |
Source | Hospital Civil de Guadalajara |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study evaluates the effect of subarachnoid hyperbaric bupivacaine on mean arterial blood pressure (MAP) of pregnant patients with obesity undergoing cesarean section half of the patients will receive subarachnoid hyperbaric bupivacaine at a dose of 5 mg while the other half will receive a dose of 10 mg
Status | Completed |
Enrollment | 40 |
Est. completion date | May 30, 2018 |
Est. primary completion date | June 30, 2017 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Patients with single fetus pregnancy =37 weeks gestation - Body mass index (BMI) = 30 kg / m2 - Indication of termination of pregnancy via abdominal caesarean section - Indication of subarachnoid neuraxial block under mixed technique - Signing of consent under information Exclusion Criteria: - Patients with a known allergy to local anesthetics - Patients with psychiatric treatment (antidepressants, anxiolytics, antipsychotics) - Patients with addiction to any type of drug - Patients with a history of liver disease - Patients with a history of renal pathology - Patients with a history of pulmonary pathology - Patients with a history of cardiac pathology - Patients with a history of high blood pressure - Patient with a history of type I, II and gestational diabetes - Non-calming fetal state - Patients who refuse the anesthetic technique of neuraxial block |
Country | Name | City | State |
---|---|---|---|
Mexico | Hospital Civil de Guadalajara | Guadalajara | Jalisco |
Lead Sponsor | Collaborator |
---|---|
Hospital Civil de Guadalajara |
Mexico,
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* Note: There are 31 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assess the mean blood pressure | Number of participants with a decrease in mean arterial blood pressure after administration of subarachnoid hyperbaric bupivacaine at a dose of 5 mg and 10 mg to preserve the mean blood pressure in pregnant patients with obesity undergoing caesarean section | 2 hours | |
Primary | Determine the effects on the heart rate | Number of participants presenting changes in heart rate such as bradycardia (heart rate less than 60 beats minute) or tachycardia (heart rate greater than 120 beats minute) after administration of subarachnoid hyperbaric bupivacaine in the pregnant patients with obesity, after subarachnoid block | 2 hour | |
Primary | Determine the effects on the respiratory rate | Number of participants presenting changes in respiratory rate such as bradypnea (respiratory rate less than 12 minute breaths) after administration of subarachnoid hyperbaric bupivacaine in the pregnant patient with obesity, after subarachnoid block | 2 hour | |
Secondary | Describe the adverse effects | Number of participants with side effects such as nausea or vomiting after administration of subarachnoid hyperbaric bupivacaine in the pregnant patient with obesity, after subarachnoid block. | 2 hours | |
Secondary | Identify the level of sensory blockade | The number of participants with adequate sensory block (thoracic dermatome 4 is defined as adequate to begin the surgical technique), the level of sensory block reached after the subarachnoid block; The sensory block was evaluated using pinprick. Every 3 minutes the first 15 minutes after the subarcnoid block. | 15 minutes | |
Secondary | Identify the intensity of motor blockade | The number of participants with adequate intensity of motor blockade achieved after subarachnoid block, the intensity of the motor block was evaluated with the bromage scale (I Free movement of legs and feet. II Just able to flex Knees with free movement of feet, III Unable to flex knees, but with free movement of feet. IV Unable to move legs or feet) Level IV was considered adequate motor block. Every 3 minutes the first 15 minutes after the subarachnoid block. | 15 minutes | |
Secondary | Measure the duration of the block | Measure the duration of the block with a dose of 5 mg and 10 mg of hyperbaric bupivacaine via subarachnoid route in pregnant patients with obesity | 2 hour | |
Secondary | Describe the adverse effects on the fetus | The number of patients with any side effect associated with the fetal bradycardia anesthetic technique (Fetal heart rate less than 120 beats minute) cardiac arrest (Fetal heart rate less than 100 beats minute) And in the newborn fetal acidosis (umbilical vein gasometry with Hydrogen Potential (pH) <7.0 or excess bases >-12 mmol/L) | 1 hour | |
Secondary | Document the Apgar score | Document the Apgar score in the newborn. (Apgar Score evaluate five sign: color, heart rate, reflex irritability, muscle tone and respiration) The score ranges from 0 to 2 per sign according to the criteria of the neonatologist, to grant a maximum score of 10 points. A grade of less than 7 points is considered low Apgar scores. This scores is registered t minute and five minutes of life. | 5 minutes |
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