Anesthesia, General Clinical Trial
Official title:
Does Desflurane Take Longer to Reach Target Endtidal Concentration in Patients With Higher Body Muscle Content: a Pragmatic Study
NCT number | NCT06026033 |
Other study ID # | 2022/11 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | February 1, 2022 |
Est. completion date | September 1, 2023 |
Verified date | December 2023 |
Source | Recep Tayyip Erdogan University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Desflurane is increasingly used in general anesthesia. Its pharmacokinetic properties are known and its distribution is easily modeled. Yet these models fail in practice. In order to increase accuracy, any model should include cardiac output, alveolar ventilation and alveolar dead space, all of which are either hard to measure or impractical, at least. A previous study performed by the same investigator showed that time to target endtidal concentration of sevoflurane is prolonged with increased cardiac output, but only if the patient has increased muscle mass. Although desflurane has lower muscle and fat solubility, our observations suggest a similar prolongation in case of increased muscle mass. The investigators aim to investigate if patient characteristics such as gender, age, height, weight, body type prolongs time to reach target endtidal desflurane concentration in low flow anesthesia.
Status | Completed |
Enrollment | 361 |
Est. completion date | September 1, 2023 |
Est. primary completion date | August 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - age > 18 years - planned elective surgery - planned inhalational anesthesia - planned use of desflurane Exclusion Criteria: - emergency surgery - use of other inhalational anesthetic agent (sevoflurane, isoflurane, nitrous oxide) - disclosed or recognized pregnancy |
Country | Name | City | State |
---|---|---|---|
Turkey | Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation | Rize |
Lead Sponsor | Collaborator |
---|---|
Recep Tayyip Erdogan University |
Turkey,
Athiraman U, Ravishankar M, Jahagirdhar S. Performance of computer simulated inhalational anesthetic uptake model in comparison with real time isoflurane concentration. J Clin Monit Comput. 2016 Dec;30(6):791-796. doi: 10.1007/s10877-015-9776-6. Epub 2015 — View Citation
Philip JH. Using screen-based simulation of inhaled anaesthetic delivery to improve patient care. Br J Anaesth. 2015 Dec;115 Suppl 2:ii89-94. doi: 10.1093/bja/aev370. — View Citation
Weber J, Missbach C, Schmidt J, Wenzel C, Schumann S, Philip JH, Wirth S. Prediction of expiratory desflurane and sevoflurane concentrations in lung-healthy patients utilizing cardiac output and alveolar ventilation matched pharmacokinetic models: A compa — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of rise in expiratory desflurane concentration | Correlation between the time required for the endtidal expiratory desflurane concentration to reach 8% and patient characteristics | intraoperative | |
Primary | Rate of rise in inspiratory desflurane concentration | Correlation between the time required for the endtidal inspiratory desflurane concentration to reach 6% and patient characteristics | intraoperative | |
Secondary | Correlation between occurrence of hypertension and patient characteristics | Correlation between occurrence of hypertension defined as any measurement of systolic arterial blood pressure > 160 mmHg and patient characteristics | intraoperative | |
Secondary | Correlation between occurrence of tachycardia and patient characteristics | Correlation between occurrence of tachycardia defined as any measurement of heart rate > 100/minute and patient characteristics | intraoperative |
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