IV Dexamethasone for Prolongation of Peripheral Nerve Block

Status Completed

Clinical Trial Summary

This is a volunteer study examining the effect of different doses of IV dexamethasone on prolongation of median nerve block in the forearm.

Clinical Trial Description

18 healthy volunteers aged 18-50 will be recruited (6 patients in each dosing group). Each volunteer will receive two forearm median nerve blocks separated by a two week washout period. One block will be conducted alongside an infusion of normal saline (control). The other block will be conducted alongside a randomised dose of IV dexamethasone (2, 4 or 8mg). The order of these interventions will be random. Blocks will be assessed quantitatively with cold and sharp sensation, electrical stimulation, quantitative sensory testing (thermal tolerance) and grip strength dynamometry. Measures or sensory and motor block including onset, intensity and duration will be compared between dosing groups. ;

Study Design

Related Conditions & MeSH terms

Anesthesia, Conduction

Clinical Trial Details

NCT number	NCT02864602
Study type	Interventional
Source	University Health Network, Toronto
Contact
Status	Completed
Phase	Phase 3
Start date	November 12, 2016
Completion date	February 20, 2018

View Details

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