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A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects

Anemia, Sickle Cell Clinical Trial

Official title:
A Phase 1 Study to Investigate Absorption, Metabolism, and Excretion After Establishment of Steady State Via GBT440 Loading and Maintenance Dosing Followed by a Single Oral Dose Administration of [14C]-GBT440 in Healthy Male Subjects

Clinical Trial Summary

This study will provide information regarding the metabolic pathway of GBT440, the need for evaluation of potential drug-drug interactions, and the need for studies in special populations. The administration of radiolabeled drug is necessary to fully characterize the rates and routes of elimination of GBT440, providing further quantitative information on the disposition of GBT440. The results from this study will permit a comprehensive comparison between animal and human routes of elimination and metabolic profiles of GBT440.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02497924
Study type Interventional
Source Global Blood Therapeutics
Contact
Status Completed
Phase Phase 1
Start date June 2015
Completion date July 2016
View Details
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