Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT04646083 |
Other study ID # |
E20147 |
Secondary ID |
|
Status |
Recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
January 14, 2021 |
Est. completion date |
December 31, 2024 |
Study information
Verified date |
February 2024 |
Source |
Texas Tech University Health Sciences Center, El Paso |
Contact |
Marc J Zuckerman, MD |
Phone |
9156306163 |
Email |
marc.zuckerman[@]ttuhsc.edu |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Diagnostic modalities for the evaluation of small bowel pathology include video capsule
endoscopy (VCE), antegrade and retrograde device-assisted enteroscopy, CT and MR enterography
(1). Despite VCE being the first-line evaluation modality, it lacks interventional
capability. Deep enteroscopy (DE) allows tissue sampling and other therapeutic interventions
with real-time endoscopic assessment. DE is usually performed with specific endoscopes
(balloon-assisted device or spiral overtube) making it time consuming and there is limited
availability since special instruments and accessories are required.(1,2) The
through-the-scope (TTS) balloon system consists of a balloon catheter designed for anchoring
in the small bowel, inserted through the instrument channel of a standard colonoscope.(3) The
catheter is advanced, the balloon is inflated and anchored in the small intestine and the
endoscope slides over the guiding catheter to the inflated balloon. The most common
indications for DE are obscure GI bleeding, iron deficiency anemia, abnormal capsule
endoscopy and chronic diarrhea. As compared to spiral, single-or double-balloon enteroscopy,
TTS (NaviAid, SMART Medical Systems Ltd, Ra'anana, Israel) is a simpler technique, which
requires less investment in infrastructure. The balloon catheter is advanced blindly in front
of a standard adult colonoscope as it bends around the curves of the small bowel. To prevent
perforation/trauma the catheter is fitted with a soft silicone tip which easily bends under
pressure.
Insertion depth can be calculated during the withdrawal of the enteroscope. The Aim of the
study: To compare the depth of maximal ileal insertion between through-the-scope balloon
enteroscopy (NaviAid) with enteroscopy using the adult colonoscope (Olympus CF-190) alone, in
the same patient, in a prospective cohort at University Medical Center of El Paso, Texas.
Description:
The Aim of the study: To compare the depth of maximal ileal insertion between
through-the-scope balloon enteroscopy (NaviAid) with enteroscopy using the adult colonoscope
(Olympus CF-190) alone, in the same patient, in a prospective cohort from August 1, 2020 to
July 31, 2023 at University Medical Center of El Paso, Texas.
Depth of insertion is correlated with diagnostic yield, meaning that we would like to
ascertain if the use of the colonoscope with NaviAid will result in greater depth of
insertion and potentially more findings of small bowel abnormalities than using a colonoscope
alone.
It is assumed that this is the case, but we want to show it and quantify it.
HYPOTHESIS:
The depth of ileal insertion is greater with the use of through-the-scope balloon enteroscopy
(NaviAid) when compared with enteroscopy using the standard adult colonoscope (Olympus
CF-190) alone.
OBJECTIVE:
To compare the depth of maximal ileal insertion between through-the-scope balloon enteroscopy
(NaviAid) with the adult colonoscope (Olympus CF-190) alone, in the same patient, in a
prospective cohort at University Medical Center of El Paso, Texas.