Androgenetic Alopecia Clinical Trial
Official title:
Pharmacogenomic Study of Androgenetic Alopecia
Androgenic alopecia, the common form of hair loss is a highly heritable disorder of
considerable social significance affecting around 40% of adult men and women. A variety of
genetic and environmental factors are likely to play a role in androgenetic alopecia.
Genetic variants in the human androgen receptor gene (AR) have been reported to be
associated with AGA in Caucasians. Other genes involved with hair loss also have been found.
One of them being a gene on chromosome 3 (3q26). A recent genome-wide association study in
296 individuals with male-pattern baldness and 347 controls had carried out and five SNPs on
chromosome 20p11 were found to be highly significant association for AGA (rs2180439 combined
P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor
locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified
androgen-independent pathway.
The total number of evaluated patients with androgenic alopecia will be at least 300. All
patients will be further grouped as good responders or poor responders to conventional
medications, such as topical minoxidil and systemic finasteride. Candidate genes potentially
involved in gout and its treatment response will be selected from the published literatures;
specifically, two resources of candidate genes will be selected: (i) genes which are known
to directly link with androgenic alopecia, and (ii) genes are potentially implicated in
particular pathways of androgen/estrogen receptors, metabolism and downstream signals, and
genes involved in anti-oxidants or hair growth. The SNP genotyping will be performed by
MALDI-TOF Mass Spectrometry. Data analysis will be performed by comparing SNPs allele
frequency between good responder and poor responder to conventional medications of patients
with androgenic alopecia and further comparing to the allele frequency of SNPs in healthy
controls. A functional study will also be done to prove the genetic association.
Status | Not yet recruiting |
Enrollment | 400 |
Est. completion date | July 2011 |
Est. primary completion date | October 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Willing to sign inform consent form - Willing to received history taking by telephone or interview - Diagnosed androgenetic alopecia by Hamilton-Norwood classification - More than 20 year-old, both sex Exclusion Criteria: - Ever had trauma over alopecia area - Cancer, infection, or other systemic disease that might interfere diagnosis - Unconfirmed diagnosis clinically or pathologically. |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | Taipei Medical University-Wan Fang Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
Taipei Medical University WanFang Hospital | Chang Gung Memorial Hospital |
Taiwan,
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