Clinical Trials Logo

Clinical Trial Summary

EAGLE is an international service improvement study to investigate the value of an educational tool delivered to surgeons and their teams to reduce the risk of anastomotic leak (leak of a join in the bowel) after right hemicolectomy or ileocaecal resection. This complication causes significant risk to life and therefore risks of leak should be minimised. The educational team of the European Society of Coloproctology has developed an online training package to deliver to 350 hospitals in 30 countries.


Clinical Trial Description

EAGLE is an international quality improvement programme to share best practice and harmonise ileo-colic anastomosis procedures through an education programme for surgeons and theatre teams. The programme has 3 main strategies: (i) enhanced pre-operative risk stratification (making sure it is safe to join the bowel together for each patient); (ii) harmonisation of surgical technique (making the join as good as it can be and checking it carefully after it is created), and (iii) implementation of an intra-operative anastomosis 'checklist' (focusing the attention of the whole theatre team at this critical stage of the operation). The investigators will use a novel scientific approach to assess the patient benefit that enables not only the quality improvement itself to be delivered to all participating hospitals but also enables collection and analysis of data to measure the effect of these measures. The best way of doing this is to embed the proposed quality improvement into a staggered implementation programme, allowing the effect to be assessed between the centres. The specific methodology proposed introduces the intervention in a step-wise fashion to all hospitals. By the end, all sites will have implemented the programme. Overall, the investigators hope to reduce the leak rate by 30% from 8.1% to 5.6% in about 4,500 patients. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04270721
Study type Interventional
Source University of Birmingham
Contact James Keatley
Phone +44 (0)121 371 8026
Email J.Keatley@bham.ac.uk
Status Recruiting
Phase N/A
Start date February 3, 2020
Completion date July 1, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT03560180 - Early Diagnosis of Anastomotic Leakage After Colorectal Surgery: Italian ColoRectal Anastomotic Leakage Study Group.
Completed NCT04292496 - Anastomotic Leak Testing in Gastrectomy N/A
Recruiting NCT03325361 - The Role of Transanal Tube Drainage as A Mean of Prevention of Anastomotic Leakage Anastomotic Leakage N/A
Completed NCT02703142 - Endoscopic Evaluation After Esophagectomy N/A
Recruiting NCT05606822 - Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract
Completed NCT04550156 - Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections N/A
Recruiting NCT04582708 - Use of NERv's Inline Device as an Early Diagnostic Method for Postoperative Complications Phase 2
Recruiting NCT04613635 - Stratafix vs. Vicryl OAGB / MGB Suture Study N/A
Completed NCT05579912 - The Diagnostic Dilemma of Anastomotic Leak in Esophagogastric Surgery
Active, not recruiting NCT02907385 - Efficacy and Safety of LifeSealâ„¢ Kit for Colorectal Staple Line Sealing Phase 3
Completed NCT04973046 - Tissue Oxygen Saturation for Esophagectomy
Completed NCT06227871 - A Retrospective Analysis of Pancreatic Injuries and Treatment Outcomes
Active, not recruiting NCT03795467 - Peripheral Perfusion Index, Haemoglobin and Blood Transfusion in Acute Surgical Patients
Not yet recruiting NCT03316677 - Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)? N/A
Completed NCT03632395 - Early Detection of Postoperative Anastomotic Leak by CT
Completed NCT03997721 - Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy
Completed NCT02937389 - Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Completed NCT02401100 - Anastomotic Leakage After Anterior Resection for Rectal Cancer - Predictive Biomarkers and Rectal Blood Flow
Not yet recruiting NCT00643084 - Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery N/A
Recruiting NCT06155175 - Risk of NSAIDs on Anastomotic Leak for Rectal Surgery