Non-invasive Detection of Anastomotic Leakage

Status Completed

Clinical Trial Summary

Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with malignant tumors of the esophagus or pancreatic head. These procedures are associated with high morbidity rates, which are strongly correlated with the occurrence of anastomotic leakage. Current diagnostic methods, including clinical, biochemical and radiological techniques are frequently inconclusive. Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of anastomotic leakage. Urinary volatile organic compounds reflect the metabolic status of an individual, which is associated with a systemic immunological response. The aim of this study was to determine the diagnostic accuracy of urinary volatile organic compounds to detect anastomotic leakage after esophagectomy or pancreaticoduodenectomy in an early phase.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Anastomotic Leak

Clinical Trial Details

NCT number	NCT03203434
Study type	Observational [Patient Registry]
Source	VU University Medical Center
Contact
Status	Completed
Phase	N/A
Start date	January 1, 2015
Completion date	March 1, 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03560180` - Early Diagnosis of Anastomotic Leakage After Colorectal Surgery: Italian ColoRectal Anastomotic Leakage Study Group.
Completed	`NCT04292496` - Anastomotic Leak Testing in Gastrectomy	N/A
Recruiting	`NCT03325361` - The Role of Transanal Tube Drainage as A Mean of Prevention of Anastomotic Leakage Anastomotic Leakage	N/A
Completed	`NCT02703142` - Endoscopic Evaluation After Esophagectomy	N/A
Recruiting	`NCT05606822` - Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract
Completed	`NCT04550156` - Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections	N/A
Recruiting	`NCT04582708` - Use of NERv's Inline Device as an Early Diagnostic Method for Postoperative Complications	Phase 2
Recruiting	`NCT04613635` - Stratafix vs. Vicryl OAGB / MGB Suture Study	N/A
Completed	`NCT05579912` - The Diagnostic Dilemma of Anastomotic Leak in Esophagogastric Surgery
Active, not recruiting	`NCT02907385` - Efficacy and Safety of LifeSeal™ Kit for Colorectal Staple Line Sealing	Phase 3
Completed	`NCT04973046` - Tissue Oxygen Saturation for Esophagectomy
Completed	`NCT06227871` - A Retrospective Analysis of Pancreatic Injuries and Treatment Outcomes
Active, not recruiting	`NCT03795467` - Peripheral Perfusion Index, Haemoglobin and Blood Transfusion in Acute Surgical Patients
Not yet recruiting	`NCT03316677` - Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)?	N/A
Completed	`NCT03632395` - Early Detection of Postoperative Anastomotic Leak by CT
Completed	`NCT03997721` - Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy
Completed	`NCT02937389` - Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Completed	`NCT02401100` - Anastomotic Leakage After Anterior Resection for Rectal Cancer - Predictive Biomarkers and Rectal Blood Flow
Not yet recruiting	`NCT00643084` - Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery	N/A
Recruiting	`NCT06155175` - Risk of NSAIDs on Anastomotic Leak for Rectal Surgery