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Clinical Trial Summary

The purpose of this study is to test the safety and efficacy of AUTO4 a CAR T cell treatment targeting TRBC1 in patients with relapsed or refractory TRBC1 positive selected T-Non-Hodgkin Lymphoma.


Clinical Trial Description

The study will consist of 2 phases, a Phase I/dose escalation phase and a Phase II/expansion phase. Patients with relapsed or refractory TRBC1 positive selected T-NHL will be enrolled in both phases of the study. Eligible patients will undergo leukapheresis to harvest T cells, the starting material for the manufacture of the autologous CAR-T product AUTO4. Following preconditioning by a chemotherapeutic regimen, the patient will receive AUTO4 intravenously as a single dose following which they will then enter a 24-month follow-up period ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03590574
Study type Interventional
Source Autolus Limited
Contact Autolus Limited
Phone +44 (0)203 911 4385
Email clinicaltrials@autolus.com
Status Recruiting
Phase Phase 1/Phase 2
Start date August 30, 2018
Completion date July 2025

See also
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