Recurrent Mantle Cell Lymphoma Clinical Trial
Official title:
A Phase 2 Study of BAY 43-9006 (IND 69896) in Chemosensitive Relapsed Aggressive Non-Hodgkin's Lymphomas
Sorafenib may stop the growth of cancer cells by blocking blood flow to the cancer and by blocking some of the enzymes needed for cell growth. This phase II trial is studying how well sorafenib works in treating patients with chemosensitive recurrent aggressive non-Hodgkin's lymphoma
PRIMARY OBJECTIVES:
I. Determine the overall response rate, including complete and partial responses, in
patients with chemosensitive, relapsed, aggressive, non-Hodgkin's lymphoma treated with
sorafenib.
SECONDARY OBJECTIVES:
I. Determine progression-free and overall survival of patients treated with this drug.
II. Determine response duration in patients treated with this drug.
OUTLINE: This is an open-label study.
Patients receive oral sorafenib twice daily in the absence of disease progression or
unacceptable toxicity.
After completion of study treatment, patients are followed periodically.
PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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|---|---|---|---|
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