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Clinical Trial Summary

This study is being conducted to help determine whether the addition of Interferon-alpha(α-IFN),which were determined sensitized the activity of Temozolomide(TMZ) in vivo and vitro, when given along with temozolomide during the monthly cycles that follow radiation, is able to delay tumor growth, shrink tumors, or impact how long people with newly diagnosed high-grade glioma.


Clinical Trial Description

This study is being conducted to help determine whether the addition of Interferon-alpha(α-IFN),which were determined sensitized the activity of Temozolomide(TMZ) in vivo and vitro, when given along with temozolomide during the monthly cycles that follow radiation, is able to delay tumor growth, shrink tumors, or impact how long people with newly diagnosed high-grade glioma. Four weeks after radiotherapy, newly diagnosed WHO III-IV glioma patients will be randomised into two groups: TMZ group or TMZ+ α-IFN groups. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01765088
Study type Interventional
Source Sun Yat-sen University
Contact Zhong-ping CHEN, MD, PhD
Phone +86-20-87343310
Email chenzhp@sysucc.org.cn
Status Recruiting
Phase Phase 3
Start date September 2012
Completion date December 2019

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