Analgesia Clinical Trial
— LARAOfficial title:
Evaluation of Plasma Concentrations of Intravenous Lidocaine and Epidural Ropivacaine When Used in Combination in Major Abdominal Surgery
Thoracic epidural analgesia (TEA) is the gold standard analgesia of the laparotomy in major abdominal surgery and can be associated with intravenous lidocaine or subtituted by intravenous lidocaine when TEA is contraindicated and in order to reduce the use of the morphinics in the perioperative period. Side effects can be paralytic ileus or nausea and vomiting and delay the enhanced recovery after surgery. Intravenous lidocaine and TEA share several properties like anti hyperalgesia, anti inflammatory effect, intestinal process, anti tumoral effect… which suggests an additive effect of their combination that was not studied yet.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | August 2023 |
Est. primary completion date | August 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Abdominal surgery by laparotomy Exclusion Criteria: - laparoscopic abdominal surgery, - TEA contraindication, - ropivacaine contraindication - intravenous lidocaine contraindication |
Country | Name | City | State |
---|---|---|---|
France | CHU Amiens | Amiens |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire, Amiens |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood lidocaine concentration (micrograms/ml) | Lidocaine blood sample will be performed 30 min before the end of the surgery | 30 minutes before the end of surgery | |
Primary | blood lidocaine concentration (micrograms/ml) | lidocaine blood sample will be performed at the end of the infusion, | at the end of the surgery (assessed up to 2 hours) | |
Primary | blood lidocaine and ropivacaine concentration (micrograms/ml) | lidocaine and ropivacaine blood sample 2 h after the ropivacaine infusion of the TEA, | at 2 hours | |
Primary | blood ropivacaine concentration (micrograms/ml) | ropivacaine blood sample 24h after the infusion of the TEA | at 24 hours |
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