Ketorolac for Moderate to Severe Abdominal Pain in Children — KETO-APP  

Analgesia Clinical Trial

Official title: Intravenous Ketorolac Vs. Morphine In Children Presenting With Suspected Appendicitis: A Pilot Single Center Non Inferiority Randomised Controlled Trial

Status Completed

Clinical Trial Summary

In children and adolescents (older than 6 years in age) who arrive in the pediatric emergency department because they have been having 5 days or less of abdominal pain (possible appendicitis), will patients who are treated with ketorolac get just as much pain relief as those patients treated with morphine?

To answer this research question, we will need a large number of patients in a study. To ensure we have enough patients, we must include many hospitals in different cities and provinces in the same study. Before doing this, though, we must first test a smaller version of the study in our center at McMaster Children's hosptial. The goal of doing this at McMaster first is to make sure or understand:

1. We can enroll enough people in our study over 1 year

2. We can make sure that all the information we collect from patients is complete and nothing is missing

3. Reasons behind why people don't want to participate in the study

4. How satisfied patients and their caregivers were with the study

Clinical Trial Description

Background/Rationale: Appendicitis is the most common emergent surgical diagnosis among children between 5-17 years in age and accounts for 8000 admissions annually. Diagnosing appendicitis is time consuming (4-6 hours) as it requires laboratory tests and ultrasonography. This occurs while patients experience significant abdominal pain secondary to infection and localized or generalized peritonitis. Opioids have been the most prescribed analgesic for patients with suspected appendicitis, despite an ongoing opioid crisis. Our research shows that 60% of physicians use morphine or other opioids, while 40% will use non-steroidal anti-inflammatory drug (NSAID) or other non-opioids. Even though ketorolac (NSAID) is commonly used in the Emergency Department (ED) for renal colic, abdominal pain and migraine headaches, and has a safer side effect profile than morphine, all such uses in children are "off label" as there are virtually no controlled trials for children to inform practice.

Objective: To determine if it is feasible to conduct a large multi-centre randomized non inferiority trial comparing ketorolac to morphine for treating moderate to severe abdominal pain, in children 6 years in age or older, with clinically suspected appendicitis.

Hypothesis: We hypothesize that it will be feasible to conduct a large trial based on a recruitment rate of ≥40% of eligible patients approached for consent.

Study Design: Our trial is a single-centre, block randomized, non-inferiority, double-dummy, doubleblind, feasibility pilot trial. Patients ≥ 6 years in age, who have ≤ 5 days of moderate-severe pain as defined by our validated 11-point verbal numeric rating scale (VNRS) ≥ 5 and are being investigated for suspected appendicitis with intravenous (IV) access in situ or ordered, will be randomized to either: (1) IV ketorolac 0.5 mg/kg up to 30 mg (intervention) + IV morphine placebo, or (2) IV morphine 0.1 mg/kg up to 5 mg (active control) + IV ketorolac placebo. The total sample size is 100 participants. The study drugs will be identical in appearance, consistency and smell. The double-dummy design will ensure blinding is maintained for bedside clinical staff, research personnel and patients. Our study prioritized patient comfort and will largely mimic standard care. Pharmacologic co-interventions will be allowed but limited to acetaminophen (commonly used as first-line therapy). Participants in both groups will be allowed rescue therapy (morphine 0.5 mg/kg) within 60 minutes of our intervention. We will screen the ED daily for eligible patients as well as include all eligible patients for the New Investigator Fund (NIF)-funded quality improvement pathway we employed to streamline care for all ED appendicitis patients. We have a robust research program in the ED that includes students, a full-time research coordinator and several paid research assistants who screen eligible patients and approach them for consent and enrollment. Our entire project can be completed with NIF support within an 18-month study period.

Primary Outcome: Feasibility of our study design is the primary outcome of this pilot trial. Primary feasibility outcomes include: (1) proportion of patients consented from total eligible patients approached; (2) proportion of patients who completed clinical outcome assessment; and, (3) proportion of missing items on individual data collection forms. Our feasibility threshold is to recruit at least 40% of eligible patients who were approached to consent. Other thresholds include recruiting ≥8 participants/month on average and having at least 90% of participants complete all the outcome assessments at 30, 60, 90 and 120 minutes.

Summary: Acute pain in children and youth is an area that is understudied and affects thousands of Canadian children. Despite short -and long-term adverse effects including dependence, and well designed comparative effectiveness trials, opioids continue to be overused in surgical patients. Ketorolac is a promising well-established NSAID that is available for IV, has a better short-term side effect profile and is not known as a substance of misuse. Our pilot will provide valuable feasibility data for a larger, future multicenter trial. ;

Related Conditions & MeSH terms

• Abdominal Pain
• Analgesia
• Appendicitis
• Child, Only
• Emergencies

• NCT number: NCT04528563
• Study type: Interventional
• Source: Hamilton Health Sciences Corporation
• Status: Completed
• Phase: Phase 3
• Start date: May 5, 2021
• Completion date: February 6, 2023