Sonography-guided Pericapsular Never Group Block for Hip Arthroplasty

Analgesia Clinical Trial

— QUASH  

Official title:

Sonography-guided Pericapsular Nerve Group Block for Hip Arthroplasty

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04480320
• Other study ID #: K-2020-085-01
• Status: Recruiting
• Phase: N/A
• Start date: September 10, 2020
• Est. completion date: March 31, 2021

Study information

• Verified date: September 2020
• Source: Guangzhou First People's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In this study, the investigator will examine the efficacy of Pericapsular nerve group (PENG) block in hip arthroplasty as a post-operative pain management technique, study the analgesia, opioid-sparing effects and motor-blocking effects of the PENG block

Description:

PENG Block group (PG) will receive 0.5%Ropivacaine in 20 ml of saline. Sham Block group (SG) will receive 20 ml of saline Patient will be sedated with IV midazolam before nerve block. After peripheral nerve block ,general anesthesia will be conducted using sufentanyl, propofol and rocuronium for induction and propofol and sevoflurane for maintenance. Tests will be operated after procedure，and recorded up to 48 hours after surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 71
• Est. completion date: March 31, 2021
• Est. primary completion date: March 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients scheduled for hip arthroplasty

Exclusion Criteria:

• allergy to local anesthetics

• infection at the injection site

• patients receiving opioids for chronic analgesic therapy

• other lower limb neuropathies

• inability to comprehend visual analog scale (VAS)

• preexist cognitive dysfunction

Related Conditions & MeSH terms

• Analgesia
• Arthroplasty
• Nerve Block

Intervention

Procedure:
• pericapsular nerve group block
Branches of both the FN and ON provide innervation to the anterior hip capsule. High and low branches of FN provided the majority of innervation to the lateral and superomedial hip capsule. The AON innervates the medial capsule.Both of the nerve close to the periosteum between the iliopubic eminence and AIIS ,by using ultrasound guided technique,these sites can be potential bony landmarks provid approch to the nerve group.

Locations

Country	Name	City	State
China	Guangzhou First Municipal People's Hospital	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou First People's Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Highest VAS score in recovery room	Highest VAS score reported in recovery room,patient will be asked questions to measure the highest VAS score experienced in the recovery room before discharge. If the patient had a unexpected long stay at recovery room, the question will be asked at the time point "2 hours after surgery end"	before recovery room discharge(up to 2 hours after surgery end)
Secondary	VAS at rest	VAS pain score while patient at rest	day0 ,day1 ,day2
Secondary	highest VAS at period	highest VAS reported at follow up period	day0 ,day1 ,day2
Secondary	quadriceps strength	Measure quadriceps strength peak value at different time point	day0 , day1 ,day2
Secondary	total opioid consumption		up to 2 days after surgery
Secondary	PONV rate	postoperative nausea and vomit	day0 ,day1 ,day2
Secondary	Fall incident happened	Record the fall incident happened,fall is defined as patinent accidently fall to the ground.	up to 2 days after surgery
Secondary	Nerve block range	A cotton yarn with ethanol will be put on both the surgical and nonsurgical leg to evaluate the cold sensation lost after nerve block.Skin sensation lost will be tested at lateral thigh,medial thigh,front thigh and lateral claf	day0 , before discharge from PACU(up to 2 hours after surgery end)