Dexamethasone Added to Levobupivacaine Improves Postoperative Analgesia

Analgesia Clinical Trial

Official title:

Dexamethasone Added to Levobupivacaine Improves Postoperative Analgesia After Supraclavicular Brachial Plexus Blockade

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01739270
• Other study ID #: 0911
• Status: Active, not recruiting
• Phase: N/A
• First received: November 25, 2012
• Last updated: July 28, 2015
• Start date: October 2012

Study information

• Verified date: July 2015
• Source: University Hospital Dubrava
• Contact: n/a
• Is FDA regulated: No
• Health authority: Croatia: Ministry of Science, Education and Sports
• Study type: Interventional

Clinical Trial Summary

Adding dexamethasone to local anesthetic will significantly prolong duration of brachial plexus anesthesia and analgesia.

Description:

Operations of upper extremities are often performed in regional anesthesia blocks. Single-injection blocks are effective, but time limited. Adding 4mg of dexamethasone to 0.5% levobupivacaine will significantly prolong duration of brachial plexus anesthesia and analgesia for fracture operations of upper extremity. This effect will result in less opioid use postoperatively.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 55
• Est. primary completion date: January 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• patients aged 18 years or older

• ASA (American Society of Anesthesiologists) physical status I, II or III

Exclusion Criteria:

• refusal of the patients to give informed consent

• preexisting coagulation disorders

• local infection at the site of the block

• neuropathy

• drug or alcohol abusers

• known allergy to the drug used in study

• operation time exceeding six hours

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Analgesia
• Brachial Plexus Anesthesia

Intervention

Procedure:
• supraclavicular brachial plexus block

Locations

Country	Name	City	State
Croatia	Clinical Hospital Dubrava	Zagreb

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Dubrava

Country where clinical trial is conducted

Croatia, 

References & Publications (3)

Kim YJ, Lee GY, Kim DY, Kim CH, Baik HJ, Heo S. Dexamathasone added to levobupivacaine improves postoperative analgesia in ultrasound guided interscalene brachial plexus blockade for arthroscopic shoulder surgery. Korean J Anesthesiol. 2012 Feb;62(2):130- — View Citation

Parrington SJ, O'Donnell D, Chan VW, Brown-Shreves D, Subramanyam R, Qu M, Brull R. Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):422-6. doi: 1 — View Citation

Vieira PA, Pulai I, Tsao GC, Manikantan P, Keller B, Connelly NR. Dexamethasone with bupivacaine increases duration of analgesia in ultrasound-guided interscalene brachial plexus blockade. Eur J Anaesthesiol. 2010 Mar;27(3):285-8. doi: 10.1097/EJA.0b013e3 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	duration of analgesia	Duration of analgesia after supraclavicular block	24 hour postoperatively	Yes
Secondary	postoperative analgesic consumption		24 hour	Yes