Anal Fistula Clinical Trial
Official title:
Ligation of Intersphincteric Fistula Tract (LIFT) Versus Rectal Advanced Mucosal Flap (RAF) in Surgical Treatment of High Perianal Fistulas
Perianal fistula is a chronic phase of anorectal infection that occurs predominantly in the
third and fourth decade of life. According to Parks classification fistulas have been
divided into intersphincteric, transsphincteric, suprasphincteric and extrasphincteric.
Simple fistulotomy can be performed with satisfactory outcomes in low fistula tracts but in
high (transsphincteric) fistulas it may affect anal continence seriously.
Therefore sphincter preserving procedures should be preferred in these cases. Rectal
advancement mucosal flap (RAF) is one of the methods used in surgical fistula eradication
with high success rate in cryptoglandular fistulas. However, this technique is technically
demanding and results can be expert depended with wide spread of healing rates (24-100%) in
individual studies as referred in recent systematic review.
Ligation of the intersphincteric fistula tract (LIFT) has been presented in 2007 as a simple
sphincter preserving technique. The success rate varies between 40-95% with low overall
incontinence rate (6%).
The aim of the study is to compare the efficacy of the LIFT and RAF procedure for treatment
of high perianal fistulas.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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