Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Anaesthesia Clinical Trial

Official title:

Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00446212
• Other study ID #: 2006.125
• Status: Completed
• Phase: Phase 4
• First received: March 8, 2007
• Last updated: May 28, 2013
• Start date: August 2006
• Est. completion date: July 2008

Study information

• Verified date: May 2013
• Source: Melbourne Health
• Contact: n/a
• Is FDA regulated: No
• Health authority: Australia: Department of Health and Ageing Therapeutic Goods Administration
• Study type: Interventional

Clinical Trial Summary

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Description:

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: July 2008
• Est. primary completion date: July 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Male and female patients

• Age between 18 and 50 years

• Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

• Inadequate English language comprehension

• Major drug abuse problem

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Anaesthesia

Intervention

Drug:
• Propofol
target controlled infusion of propofol
• desflurane
Anaesthetic maintenance with desflurane

Locations

Country	Name	City	State
Australia	Royal Melbourne Hospital	Parkville	Victoria
Australia	Royal Perth Hospital	Perth	Western Australia
Australia	King Edward Memorial Hospital for Women	Subiaco	Western Australia
New Zealand	Waikato Hospital	Hamilton

Sponsors (1)

Lead Sponsor	Collaborator
Melbourne Health

Countries where clinical trial is conducted

Australia,  New Zealand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire		recovery room stay	No