Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Anaesthesia Clinical Trial

Official title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Status Completed

Clinical Trial Summary

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Clinical Trial Description

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Anaesthesia

• NCT number: NCT00446212
• Study type: Interventional
• Source: Melbourne Health
• Status: Completed
• Phase: Phase 4
• Start date: August 2006
• Completion date: July 2008