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Anaemia clinical trials

View clinical trials related to Anaemia.

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NCT ID: NCT01528644 Completed - Iron Deficiency Clinical Trials

Iron & Alginate Study

Start date: February 2012
Phase: N/A
Study type: Interventional

Iron deficiency anaemia affects around two billion people worldwide. Food fortification with iron is a realistic way to combat this problem. Water soluble forms of iron are considered to be more bioavailable than nonsoluble iron compounds. However, the former often cause sensory problems when added to foods, while the latter cause fewer problems but are not generally well absorbed and are therefore ineffective as fortificants. A potential strategy for overcoming this problem is the use of water soluble iron compounds protected by a water resistant barrier, which will prevent potential organoleptic changes within fortified foods and protect the iron (from oxidation) through the digestion process thus increasing its availability. The investigators will use alginate, in the form of alginate beads, as a protective barrier for soluble iron gluconate. It has been shown that alginates bind divalent and trivalent cations and therefore may be a useful vehicle for soluble iron compounds to fortify foods. The aim of this project is to measure the effect of alginate on iron absorption from ferrous gluconate and assess the potential modulating effect of calcium on iron absorption in the presence and absence of alginate.

NCT ID: NCT01490944 Recruiting - Anaemia Clinical Trials

Impact of Vitamin B12 Supplementation With Iron and Folic Acid on Adolescent Girls

Start date: January 2012
Phase: Phase 2
Study type: Interventional

The study is a clinical trial to assess the effectiveness of Vitamin B12 supplementation along with Iron Folic Acid (IFA) in combating anaemia. Adolescent anaemic girls will be randomly divided into two groups. - Group 1: IFA weekly supplementation along with Information, Education, Communication sessions - Group 2: IFA + Cyanocobalamin weekly supplementation along with Information, Education, Communication sessions Duration of supplementation: 6 months

NCT ID: NCT01454752 Completed - Malaria Clinical Trials

Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and Cognition

Start date: November 2011
Phase: N/A
Study type: Interventional

Although the risk of malaria is greatest in early childhood, significant numbers of schoolchildren remain at risk from malaria infection, clinical illness and death. By the time they reach school, many children have already acquired some clinical immunity and the ability to limit parasite growth, and thus most infections are asymptomatic and will go undetected and untreated. Asymptomatic parasitaemia contributes to anaemia, reducing concentration and learning in the classroom, and interventions aiming to reduce asymptomatic parasite carriage may bring education, as well as health, benefits. Intermittent parasite clearance (IPC) delivered through schools is a simple intervention, which can be readily integrated into broader school health programmes, and may usefully supplement the community-distribution of insecticide-treated nets (ITNs) in countries with a policy of universal coverage of nets. This study seeks to establish whether intermittent parasite clearance undertaken once a year at the end of the malaria transmission season can reduce malaria parasite carriage and anaemia amongst school-going children already using insecticide-treated nets, and its consequent impact on school attendance and performance, in order to assess its suitability for inclusion as a standard intervention in school health programmes in areas of seasonal malaria transmission.

NCT ID: NCT01431118 Completed - Anaemia Clinical Trials

Iron Metabolism in Dragon Boat Athletes

Start date: April 2011
Phase: N/A
Study type: Interventional

The purpose of the study is: - To investigate the effect of sport-specific stress in the iron metabolism of dragon boat athletes - To investigate the effects of sport-specific stress in the activity of pro-hepcidin and hepcidin

NCT ID: NCT01410435 Completed - Clinical trials for Inflammatory Bowel Disease

Safety and Efficacy Extension Study of Iron Isomaltoside 1000 (Monofer®) in Subjects With Inflammatory Bowel Disease

Start date: June 2011
Phase: Phase 3
Study type: Interventional

Since the duration of most studies with IV iron in IBD subjects have been only 4-12 weeks studies there is a need to follow-up on long term safety and efficacy of any maintenance iron therapy. This study represents subjects from the Lead-in Study (P-Monofer-IBD-01) on iron isomaltoside 1000 (Monofer®) to assess the long term safety of iron isomaltoside 1000 (Monofer®) and its ability to maintain stable haemoglobin in IBD subjects with Iron Deficiency Anaemia (IDA).

NCT ID: NCT01406340 Terminated - Anaemia Clinical Trials

Assessment of the Pharmacokinetics of GSK1278863 and Metabolites in Normal Subjects and Subjects With Renal Impairment

Start date: August 30, 2011
Phase: Phase 1
Study type: Interventional

This will be an open-label, parallel-group study to evaluate the pharmacokinetics of GSK1278863 and metabolites in normal subjects and subjects with impaired renal function, including those who are hemodialysis dependent. GSK1278863 will be administered once daily for 14 days to normal subjects and subjects with Stage 3 and Stage 4 renal function, and 15 days to subjects with Stage 5 renal function. Pharmacokinetic assessments will be made on Days 1 and 14 (normal subjects, subjects with Stage 3 and Stage 4 renal function) or Days 14 and 15 (dialysis and non-dialysis days; Stage 5).

NCT ID: NCT01376232 Completed - Anaemia Clinical Trials

Study to Assess the Pharmacokinetics of GSK1278863A Coadministered With a High Fat Meal or an Inhibitor of CYP2C8 (Gemfibrozil)

DDI
Start date: November 8, 2010
Phase: Phase 1
Study type: Interventional

Study to Assess the Pharmacokinetics of GSK1278863A Coadministered with a High Fat Meal or an Inhibitor of CYP2C8 (gemfibrozil),]

NCT ID: NCT01319006 Completed - Anaemia Clinical Trials

Relative Bioavailability Study for GSK1278863A

Start date: February 25, 2011
Phase: Phase 1
Study type: Interventional

A randomized, open-label, 3-period crossover study.

NCT ID: NCT01136850 Completed - Anaemia Clinical Trials

Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea

IPTp in PNG
Start date: November 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether repeated courses of sulphadoxine-pyrimethamine (SP) in combination with azithromycin given at Antenatal Clinic, leads to lower rates of low birth weight deliveries (<2.5 kg) among Papua New Guinean women, than the current standard treatment of SP and chloroquine.

NCT ID: NCT01131624 Completed - Anaemia Clinical Trials

Comparative Efficacy and Safety of Intravenous Ferric Carboxymaltose (FCM) Versus Oral Iron for Iron Deficiency Anaemia in Pregnant Women

ASAP
Start date: May 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to look at how well Ferric Carboxymaltose, an intravenous iron therapy (iron that is infused directly into your body through a vein), compares with ferrous sulphate capsules taken by mouth in the treatment of iron deficiency anaemia during pregnancy.