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Quantitative and Repetitive TMS in ALS — QuARTS-ALS  

Amyotrophic Lateral Sclerosis Clinical Trial

Official title:
A Biomarker-Directed Neuromodulation Trial Using Quantitative and Repetitive Transcranial Magnetic Stimulation in Amyotrophic Lateral Sclerosis (The QuARTS-ALS Trial)

Clinical Trial Summary

The goal of this open-label pilot clinical trial is to evaluate the safety, tolerability and target engagement of accelerated, high dose continuous theta-burst stimulation (cTBS) using transcranial magnetic stimulation (TMS) in patients with ALS.

Clinical Trial Description

The purpose of this study is to: 1. Evaluate the safety and feasibility of cTBS neuromodulation with bilateral repetitive TMS treatment using an accelerated schedule in patients with ALS. 2. Assess the changes in corticospinal excitability using quantitative single- and paired-pulse TMS measures. 3. Assess the changes in MR spectroscopy of glutamate and GABA spectra after cTBS neuromodulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05983211
Study type Interventional
Source Sunnybrook Health Sciences Centre
Contact Agessandro Abrahao, Dr.
Phone (416) 480-6100
Email alsresearch@sunnybrook.ca
Status Recruiting
Phase N/A
Start date June 1, 2023
Completion date April 15, 2026
View Details
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