Multiple Doses of AT-1501-A201 in Adults With ALS

Status Completed

Clinical Trial Summary

This is a Phase 2a, multi-center, open label, multiple dose study of AT-1501, a humanized monoclonal antibody antagonist to CD40 ligand (CD40L). Approximately 54 adults with Amyotrophic Lateral Sclerosis (ALS) will be enrolled into the study in the United States and Canada at approximately 13 ALS treatment sites. Participants will be enrolled into one of four ascending doses.

Clinical Trial Description

This is a Phase 2a, multi-center, open label, multiple dose study of AT-1501, a humanized monoclonal antibody antagonist to CD40L. Approximately 54 adults with ALS will be enrolled into the study in the United States and Canada at approximately 13 ALS treatment sites. Four ascending doses of AT-1501 will be administered as an IV infusion to sequentially enrolling cohorts. Each participant will receive 6 bi-weekly (every other week) infusions of AT-1501 over an 11-week period. The study is estimated to take 19 weeks for participants. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04322149
Study type	Interventional
Source	Eledon Pharmaceuticals
Contact
Status	Completed
Phase	Phase 2
Start date	October 16, 2020
Completion date	March 24, 2022

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