Environmental Exposure and Neurological Diseases Questionnaire

Amyotrophic Lateral Sclerosis Clinical Trial

— Cleveland Ohio  

Official title:

Case-control and Population Questionnaire Studying Environmental Risk Factors and Neurological Diseases

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02916966
• Other study ID #: D06019
• Status: Completed
• Start date: October 2016
• Est. completion date: September 2023

Study information

• Verified date: April 2024
• Source: Dartmouth-Hitchcock Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA (beta-methylamino-L-alanine), and other environmental toxins/toxicants as risk factors for ALS. This work will advance the mission of the Centers for Disease Control Agency for Toxic Substances and Disease Registry (CDC ATSDR) National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 460
• Est. completion date: September 2023
• Est. primary completion date: September 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• ALS

• Non-neurodegenerative controls

• Can willingly give consent

• Over 18 years of age

Exclusion Criteria:

• Cannot give consent

• Under 18 years of age

Related Conditions & MeSH terms

• Amyotrophic Lateral Sclerosis
• Motor Neuron Disease
• Nervous System Diseases

Intervention

Other:
• Patient Registry
Patient Registry

Locations

Country	Name	City	State
United States	Cleveland Clinic Foundation	Cleveland	Ohio

Sponsors (2)

Lead Sponsor	Collaborator
Dartmouth-Hitchcock Medical Center	The Cleveland Clinic

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Questionnaire for Environmental Exposures, Toxins, and Neurological Disease		1 year