Amyotrophic Lateral Sclerosis Clinical Trial
Official title:
Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is characterized clinically by abnormalities of both
upper motor neurons (UMN) and lower motor neurons (LMN). The presence of UMN signs is not
always easy to establish. The only technique used in routine to assess the corticospinal
dysfunctions is based on transcranial magnetic stimulation (TMS). However, this technique is
largely dependent on LMN state and is based on artificial motor cortex activation.
The main objective of our study project is to evaluate a new method assessing functional
changes in motor system in ALS patients. By using cortico-muscular and cortico-cortical
coherences, it could be possible to show modifications in both cortico-muscular relationship
and in cortical activity coordination which could be related to clinical state in ALS
patients. We notably expect a decrease in cortico-muscular coherence in ALS patients.
Furthermore, these analyses could provide new insights in motor system plasticity phenomena.
We expect a partial covering of voluntary motor command by cortical areas adjacent to
primary motor cortex. Lastly, the hypothesis that an increased proportion of voluntary motor
control may be assumed by ipsilateral corticospinal tract could be tested by coherence
analyses.
Coherence analysis might be a useful method to detect corticospinal tract dysfunctions. This
method has the advantage to be painless and not to use artificial stimulations as it is used
in TMS.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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