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Amyotrophic Lateral Sclerosis clinical trials

View clinical trials related to Amyotrophic Lateral Sclerosis.

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NCT ID: NCT06169176 Available - Clinical trials for Amyotrophic Lateral Sclerosis

RAPA-501 Therapy for ALS EAP

Start date: n/a
Phase:
Study type: Expanded Access

RAPA-501-ALS is an Intermediate-Size Expanded Access Trial of RAPA-501 autologous hybrid TREG/Th2 cells in patients living with amyotrophic lateral sclerosis (pwALS).

NCT ID: NCT06069934 Available - Clinical trials for Amyotrophic Lateral Sclerosis

Pridopidine in Amyotrophic Lateral Sclerosis (EAP 2)

Start date: n/a
Phase:
Study type: Expanded Access

This EAP will provide access to pridopidine for up to 200 patients with ALS who are ineligible for clinical trials. Pridopidine will be given at a dose of 45 mg twice daily p.o. (or via feeding tube). Each patient will be followed for 2 years with regularly scheduled visits. The screening and baseline visits will be performed in person; subsequent visits may occur in person or remotely. Recommended in-person visits will occur at Weeks 4, 12, 28, 52, 78, and end of treatment (Week 104 or early termination). If the patient is unable to complete the visits in person, these visits may also be completed remotely.

NCT ID: NCT05597436 Available - Clinical trials for Amyotrophic Lateral Sclerosis

Intermediate-Sized Expanded Access Study

Start date: n/a
Phase:
Study type: Expanded Access

This expanded access protocol is to provide access to the investigational product, SLS-005, to participants with ALS who are not eligible to participate in clinical trials.

NCT ID: NCT05281484 Available - Clinical trials for Amyotrophic Lateral Sclerosis

Intermediate Expanded Access Protocol (EAP) CNMAu8.EAP02

Start date: n/a
Phase:
Study type: Expanded Access

The primary objective of the intermediate expanded access protocol is to provide access to the investigational product, CNM-Au8, to up to 300 people living with ALS (pALS). No formal clinical hypotheses are being evaluated with concurrent controls. Secondary objectives include assessment of the safety of CNM-Au8 treatment in pALS. Safety will be assessed through the frequency of serious adverse events (SAEs), treatment-emergent adverse events (TEAEs) assessed as 'severe', discontinuations due to TEAEs, and laboratory abnormalities assessed as clinically significant during routine clinical monitoring (as applicable).

NCT ID: NCT04081714 Available - Clinical trials for Amyotrophic Lateral Sclerosis

Intermediate Expanded Access Protocol for ALS

Start date: n/a
Phase:
Study type: Expanded Access

This is a single-center intermediate expanded access program to provide access to the investigational product, CNM-Au8, up to 40 participants diagnosed with ALS.