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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01406314
Other study ID # 114527
Secondary ID
Status Completed
Phase Phase 1
First received July 26, 2011
Last updated June 7, 2017
Start date October 13, 2011
Est. completion date November 14, 2012

Study information

Verified date June 2017
Source GlaxoSmithKline
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study aims to provide safety information on the ligand, GSK2315698A. The pharmacokinetics and pharmacodynamics of the ligand will be determined together with the differences in routes of dose administration, namely the tolerability between intravenous versus subcutaneous dose administration. The study will be carried out in patients with systemic amyloidosis and the ability of GSK2315698A in depleting levels of serum amyloid protein (SAP) will be measured.


Description:

This study is an open label, dose characteristic study assessing safety and pharmacokinetic and pharmacodynamic considerations of GSK2315698A. GSK2315698A is a ligand known to bind to serum amyloid protein (SAP), a key component of an anti-SAP approach to the treatment of systemic amyloidosis. Safety assessments will include adverse events, vital signs, ECGs and other relevant clinical laboratory tests. Dose administration routes will also be determined focusing on the tolerability of intravenous dose administration versus subcutaneous. The study aims to recruit up to 30 patients with a medical diagnosis of systemic amyloidosis. Subjects will be asked to attend 2 dosing sessions, each session will involve an intravenous infusion of GSK2315698A over 48 hours followed by a single subcutaneous dose in session 1 and up to 3 subcutaneous doses in session 2 to be administered over a 24 hour period.


Recruitment information / eligibility

Status Completed
Enrollment 17
Est. completion date November 14, 2012
Est. primary completion date November 14, 2012
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- medically diagnosed with systemic amyloidosis

- AST,ALT, alkaline phosphatase <= 3xULN and bilirubin ,1.5xULN

- undergone radio-labelled-SAP scanning as part of their routine clinical care

- male or female between 18 and 80 years of age inclusive, at time of signing the informed consent

- subject is ambulant and capable of attending CUC

- capable of giving written consent, which includes compliance with the requirements of the requirement and restrictions listed in the consent form

- a female subjects is eligible to participate if she is of non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea

- male subjects with female partners of child-bearing potential must agree to use contraception methods listed in the protocol and informed consent information. This must be followed from the time of the first dose of study medication to 85 days post-last dose.

- smokers (<10 cigarettes a day) are permitted but must be willing to abstain for the duration of residential study sessions

Exclusion Criteria:

- a positive pre-study Hepatitis B surface antigen or Hepatitis C antibody result within 3 months of screening

- the subject has participated in a clinical trial and has received an investigational therapeutic product (unlicensed) within 3 months, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer)

- pregnant females as determined by positive serum or urine hCG test at screening or prior to dosing

- lactating females

- unwillingness or inability to follow the procedures outlined in the protocol

- subject is mentally or legally incapacitated

- renal failure requiring haemodialysis will normally result in exclusion. Subjects in patient group 4 on haemodyalysis may be considered providing their schedule of dialysis can be accommodated within the study schedule

- decompensated cardiac failure or recent history of syncope

- clinically significant anaemia - Hb<9g/dL

- use of prohibited medications

- poor or unsuitable venous access

- subjects with a QTc of > or equal to 480ms or other ECG abnormalities which, in the opinion of the investigator, is clinically significant in that they may increase safety risk

- uncontrolled hypertension with systolic BP> 170mm Hg and/or diastolic >100 mm Hg

- previous surgical procedures that result in altered anatomy of the upper digestive tract including cholecystectomy (gall bladder removal) will result in exclusion from the Entero-Test procedure, but the subject may still participate in the study

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
GSK2315698
Intravenous infusion for approximately 48hours followed by subcutaneous injection

Locations

Country Name City State
United Kingdom GSK Investigational Site Cambridge

Sponsors (1)

Lead Sponsor Collaborator
GlaxoSmithKline

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Blood concentrations of SAP comparison of predicted vs observed 19 weeks
Primary Plasma concentrations of GSK2315698 changes in plasma concentrations of GSK2315698 over time 19 weeks
Secondary safety and tolerability of GSK2315698 evaluated by adverse event (AE) reporting, clinical laboratory tests, vital signs, and 12-lead electrocardiogram (ECG). 19 weeks
Secondary Change from baseline in blood SAP levels evaluate effect of GSK2315698 on SAP levels in the blood 19 weeks
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