Amyloidosis Cardiac Clinical Trial
Official title:
Impact of Cardiac Amyloidosis on Patients With Severe Aortic Stenosis Who Undergo Transcatheter Aortic
To analyze the prevalence and impact on the prognosis of amyloidosis due to transthyretin in patients with severe aortic stenosis who undergo percutaneous aortic valve implantation.
Type and design of the study: Multicentric, prospective cohort, observational.
Number and characteristics of the patients: 321 patients to whom TAVI has been implanted due
to severe degenerative AS.
Duration of the study
- Recruitment period: All consecutive patients undergoing a non-invasive diagnostic study
of amyloidosis (scintigraphy with technetium pyrophosphate99 and blood protein
electrophoresis) will be recruited before discharge, in centers with proven experience,
will accept non-invasive diagnosis with resonance) and have an implanted percutaneous
aortic prosthesis for severe aortic stenosis.
- Follow-up period: clinical and echocardiographic follow-up will be carried out before
discharge, in consultation at three, six, twelve and twenty-four months.
Inclusion: 1 year
Follow up: 2 years
Data analysis: 6 months
Total: 3 years and 6 months
Events
- Main event: cardiovascular events (cardiovascular death, stroke, infarction)
- Secondary events: death from any cause, readmission due to heart failure, pacemaker
implantation, functional class evaluation
Countries and participating centers: Various Spanish and international centers will be
invited to participate.
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