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Prospective Study on the Role of Intravenous Unfractionated Heparin Following Digital Replantation and Revascularization

Amputation; Traumatic, Hand Clinical Trial

Official title:
Prospective Study on the Role of Intravenous Unfractionated Heparin Following Digital Replantation and Revascularization

Clinical Trial Summary

The purpose of this study is to determine the effectiveness of therapeutic dose intravenous heparin at improving replantation/revascularization success and its indications (if any) in participants who have suffered traumatic digital amputation. Digital replantation/revascularization success will be assessed in participants who receive continuous intravenous drip of thromboprophylactic heparin at a therapeutic dose (i.e. modifies INR to the desired range) contrasted to those who do not receive therapeutic dose heparin (i.e. does not modify INR to the desired range). In the study, replantation/revascularization success is defined as a clearly viable digit at the time of discharge. Secondary objectives include assessing postoperative complications associated with heparin use, such as bleeding, hematoma or heparin induced thrombocytopenia. The investigators would also assess the impact of categorical variables such as smoking status, mechanism of injury and comorbidities, on digital survival.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04725201
Study type Interventional
Source Centre hospitalier de l'Université de Montréal (CHUM)
Contact Linda M Zhu
Phone 5148908000
Email linda.zhu@mail.mcgill.ca
Status Recruiting
Phase Phase 4
Start date May 24, 2021
Completion date May 1, 2025
View Details
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