Paired-pulse rTMS Treatment for Methamphetamine Use Disorder Based on the Frontopolar-Cerebellum

Amphetamine Use Disorders Clinical Trial

Official title:
Exploration of the Intervention Mechanism and Efficacy of Paired-pulse rTMS Treatment for Methamphetamine Use Disorder Based on the Frontopolar-Cerebellum

Status Recruiting

Clinical Trial Summary

To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired frontopolar cortex (FPC) -cerebellar pulses on episodic methamphetamine use in patients on methadone maintenance treatment and to develop a novel physiotherapeutic intervention to optimise the treatment and management of addicted patients.

Clinical Trial Description

Numerous studies have shown that impaired FPC-cerebellar functional connectivity leads to impaired social preferences and behavioural flexibility and more persistent drug use in addicts. Cerebellar and FPC paired-pulse rTMS interventions may enhance functional connectivity, effectively modulate cerebellar-prefrontal loops, reduce craving, improve cognitive flexibility, and reduce relapse risk. The aim of this project is to explore the mechanism and efficacy of a novel FPC-cerebellar paired-pulse rTMS intervention model on occasional methamphetamine use in methadone maintenance patients, to develop novel physiotherapy interventions, and to optimise the treatment and management of addicted patients. ;

Study Design

Related Conditions & MeSH terms

Amphetamine Use Disorders

Clinical Trial Details

NCT number	NCT06457230
Study type	Interventional
Source	Shanghai Mental Health Center
Contact	Min Zhao, PhD
Phone	64387250
Email	drminzhao@gmail.com
Status	Recruiting
Phase	N/A
Start date	September 2024
Completion date	December 2025

View Details

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