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Clinical Trial Summary

This is a proof-of-concept randomized clinical trial of psilocybin-enhanced psychotherapy versus treatment-as-usual among individuals being treated for methamphetamine use disorder.


Clinical Trial Description

The trial will take place with individuals admitted to a residential rehabilitation treatment program. The treatment protocol will consist of 4 preparatory therapy visits, 2 psilocybin sessions (25-30mg), and 8 total integration therapy visits. Primary aims assess acceptability, feasibility, and safety with a primary endpoint at the conclusion of the study intervention. An additional aim assesses preliminary efficacy for methamphetamine use disorder and overall functioning at follow-up assessments 60 and 180 days after discharge from the residential treatment program. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04982796
Study type Interventional
Source Portland VA Research Foundation, Inc
Contact Jenna Kachmarik, BS
Phone (971) 409-7908
Email Jenna.Kachmarik@va.gov
Status Recruiting
Phase Phase 1/Phase 2
Start date July 7, 2022
Completion date April 30, 2025

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