Ammonia Metabolism Clinical Trial
Official title:
L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients
L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.
| Status | Recruiting |
| Enrollment | 80 |
| Est. completion date | April 2018 |
| Est. primary completion date | April 2018 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - patients were those surgically treated for hepato-biliary diseases Exclusion Criteria: - Patient exclusion criteria included a body weight loss greater than 10% during the six months prior to surgery, the presence of distant metastases, or seriously impaired function of vital organs due to respiratory, renal or heart disease. |
| Country | Name | City | State |
|---|---|---|---|
| Japan | Kochi Health Sciences Center | Kochi |
| Lead Sponsor | Collaborator |
|---|---|
| Kochi University |
Japan,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | postoperative ammonia levels | change from preoperative baseline at postoperative day 1 and day3 | 3 points; preoperative baseline, postoperative day 1, and day3 | |
| Secondary | length of hospitalization after liver resection | postoperative days | up to 24 weeks |