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Vinblastine for Leukoreduction in Newly Diagnosed AML and Hyperleukocytosis

AML Clinical Trial

Official title:
Vinblastine Versus Oral Hydroxiurea in Newly Diagnosed AML With Hyperleukocytosis: a Phase 2 Clinical Study

Clinical Trial Summary

Vinblastine can leukoreduce patients with newly diagnosed AML and hyperleukocytosis but clinical trials are lacking.

Clinical Trial Description

This phase 2 trial will explore the efficacy of a single dose of vinblastine (6mg/m2) to leukoreduce patients with newly diagnosed AML and hyperleukocytosis. Patients will be allocated 1:1 into two groups: intravenous single dose vinblastine or oral hydroxiurea (50mg/kg/day until response or induction chemotherapy). Effective leukoreduction and safety parameters will be compared. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05062278
Study type Interventional
Source Hospital Universitario Dr. Jose E. Gonzalez
Contact Andres Gomez
Phone 818470002
Email drgomezdeleon@gmail.com
Status Recruiting
Phase Phase 2
Start date July 26, 2021
Completion date December 1, 2025
View Details
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